瑞舒伐他汀药物对颈动脉粥样硬化斑块硬化程度的影响

Rosuvastatin in Patients with Coronary Heart Disease and Hardening of the Degree of Carotid Atherosclerotic Plaques

目的探讨分析瑞舒伐他汀药物对颈动脉粥样硬化斑块硬化程度的影响。方法对2014年2月至2015年12月期间,在我院治疗的颈动脉粥样硬化患者132例作为研究对象,随机分为研究组66例和对照组66例,研究组应用瑞舒伐他汀联合阿司匹林药物治疗,对照组采用常规药物阿司匹林治疗,观察比较两组患者的血脂水平变化情况及颈动脉粥样硬化斑块硬化(IMT)程度的改善情况。结果两组的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)水平较治疗前均有降低,高密度脂蛋白胆固醇(HDL-C)水平较治疗前有升高,研究组变化更显著,组间差异有统计学意义(P<0.05)。两组颈动脉粥样硬化斑块硬化程度较治疗前有改善,研究组优于对照组,差异有统计学意义(P<0.05)。研究组与对照组治疗总有效率分别为(98.5%)、(71.2%),差异显著(P<0.05)有统计学意义。结论瑞舒伐他汀药物能够有效的降患者的血脂水平,并能减小其颈动脉粥样硬化的程度。

Objective To explore and analyze the Rosuvastatin felling of carotid atherosclerotic plaques hardening degree of influence. Methods During February 2013 to December 2014,132 cases of coronary heart disease patients treated in our hospital as the research object,66 cases were randomly divided into research group and the control group 66 cases, the team applied rui shu laval statin （Rosuvastatin Calcium, RC ）treatment, the control group using conventional drug treatment, observe the comparison of two groups of patients with blood lipid level and the changes of carotid atherosclerotic plaques sclerosis degree of improvement. Results Two groups of total cholesterol （total cholesterol, TC ）, low density lipoprotein cholesterol （ Low density lipoprotein cholesterol, LDL- C ）, triglycerides （ TrIglyceride, TG） levels are lower than before treatment, high density lipoprotein cholesterol （ High density lipoprotein cholesterol, HDL- C ） level higher than before treatment, the team changes more significant, difference between groups was statistically significant （P 〈 0.05 ）. Two groups of carotid atherosclerotic plaques hardening degree was improved, the team is better than that of control group, the difference was statistically significant （P 〈 0. 05 ）. Treatment group and control group total effective rate （98.5 % ）, respectively （71.2% ） and significant difference （ P 〈 0. 05 ） was statistically significant. Conclusion Rosuvastatin can effectively reduce blood lipid levels in patients with coronary heart disease, and can reduce the degree of carotid atherosclerosis, clinical treatment effect is better, higher clinieal value.