辛伐他汀联合低相对分子质量肝素治疗急性肺血栓栓塞症

Effect of Simvastatin Combined with Low Molecular Weight Heparin on the Curative Effect of Patients with Acute Pulmonary Thromboembolism

目的观察辛伐他汀联合低相对分子质质量(LMWH)肝素治疗急性肺血栓栓塞(PTE)的疗效,并观察其对患者血清指标CRP、IL-8和TNF-α、凝血纤溶指标Fbg、D-D、AT及PT的影响。方法选取65例于我院治疗的急性PTE患者作为研究对象,随机分为对照组(32例)和研究组(33例)。所有患者均经接受常规治疗,在此基础上对照组采用LMWH治疗,研究组采用辛伐他汀+LMWH联合治疗。对比分析两组患者的疗效、血清指标及凝血纤溶指标。结果治疗前,两组患者血清CRP、IL-8和TNF-α指标比较均无显著统计学差异(P>0.05),治疗后,两组患者上述指标较治疗前均显著降低(P<0.05),且研究组较对照组下降更为明显(P<0.05);两组患者治疗前Fbg、D-D、AT及PT指标比较差异均不明显(P>0.05)。观察组上述指标治疗前后比较均显著改善P<0.05);对对照组治疗有效率为81.25%,与研究组的治疗有效率90.91%(P<0.05)。结论辛伐他汀联合LMWH治疗急性PTE具有较好的疗效,能显著降低患者血清炎症水平,调节体内凝血纤溶状态平衡。

Objective To study effect of simvastatin combined with low molecular heparin （LMWH） in the treatment of acute pulmonal7 thromboembolism （PTE） and the serum index of patients, effects of coagulation and fibrinolysis. Methods 65 cases of acute PTE patients treated in our hospital as the research object, using stratified random method were divided into control group（ 32 cases）and study group（ 33 cases）. All patients were treated with routine treatment,on the basis of the control group usingLMWH treatment, study group was treated with simvastatin and LMWH treatment. After a course of treatment compared the effect of two groups of patients, serum parameters and indexes of coagulation. Results Before treatment, two groups of patients with serum CRP, IL-8 and TNF-α index showed no significant statistical difference（ P 〉 0. 05 ） , after treatment,the two groups in the above indicators were significantly lower than before treatment （ P 〈 0.05 ） , and the study group decreased more obvious than the control group, the difference was statistically significant （ P 〈 0.05 ） ; Fbg. D- D treatment group two patients, AT and PT index difference was not obvious （ P 〉 0. 05 ）. The observation group before and after treatment of the above indexes were significantly improved （ P 〈 0.05 ）. the control group treatment effective rate was 81.25%, the difference was statistically significant compared with the effective rate of the study group 90. 91% （ P 〈 0.05 ）. Conclusion simvastatin and LMWH has better efficacy in the treatment of acutePTE, can significantly reduce the serum levels of inflammation in patients,improve body coagulation fibrinolytic balance.