不同剂量西地那非治疗新生儿肺动脉高压合并下肢深静脉血栓的疗效

The Effect of Different Doses of Sildenafil in the Treatment of Lower Extremity deep Venous Thrombosis and Pulmonary Artery Pressure of the Newborn

目的观察不同剂量西地那非在新生儿肺动脉高压合并患者中的临床效果。方法取2015年3月至2016年10月医院收治新生儿肺动脉高压合并下肢深静脉血栓患者80例,随机数字法分为对照组(n=40)和观察组(n=40)。对照组采用1.0 mg/(kg·d)西地那非治疗,观察组采用2.0 mg/(kg·d)西地那非治疗,比较两组临床疗效。结果两组治疗前肺动脉压及二氧化碳血氧分压水平比较差异无统计学意义(P>0.05);观察组治疗后肺动脉压及二氧化碳血氧分压水平,低于对照组(P<0.05);观察组治疗后药物不良反应发生率为7.50%,对照组为5.00%(P>0.05)。结论新生儿肺动脉高压合并下肢深静脉血栓患儿采用2.0 mg/(kg·d)西地那非治疗效果较为理想。

Objective To observe the clinical effect of different doses of sildenafil in patients with pulmonary hypertension of the newborn. Methods 80 cases of neonatal pulmonary hypertension complicated with lower extremity deep venous thrombosis in our hospital from March 2015 to 2016 were randomly divided into control group （ n = 40） and observation group （ n = 40 ）. The control group was treated with 1.0 mg/（ kg · D） sildenafil treatment, observation group were treated with 2.0 mg/（ kg · D）sildenafil treatment, compared 2 groups of clinical curative effect. Results The 2 groups before treatment, pulmonary artery pressure and partial pressure of carbon dioxide levels had no significant difference （ P 〉 0. 05 ） ; the observation group after treatment, pulmonary artery pressure and partial pressure of carbon dioxide levels lower than the control group （ P 〈 0. 05） ;the patients in the observation group the incidence of adverse reaction was 7.50% and 5% in the control group （ P 〉 0.05 ）. Conclusion Neonatal pulmonary hypertension in patients with lower extremity deep venous thrombosis were treated with 2.0mg/（ kg · d ） the curative effect of sildenafil, it is worthy of popularization and application.