鼻内镜下鼻用激素明胶海绵对鼻窦炎术腔迁延性炎症的疗效

Efficacy of gelation sponge with intranasal corticosteroids on nasal mucosal persistent refractory inflammation after endoscopic sinus surgery

目的研究鼻内镜下应用鼻用激素(糠酸莫米松)明胶海绵对鼻窦炎术腔迁延性炎症的疗效。方法 2013年9月~2014年10月共收集25例鼻窦炎术后患者。研究组11例,在清理术腔后,用糠酸莫米松明胶海绵覆盖术腔,前2周,每周2次;后2周,每周1次。对照组14例,只进行术腔清理,2周清理1次,共4周。2组都进行常规药物治疗。治疗前后分别进行视觉模拟评分(VAS)和鼻内镜检查量化评分。结果治疗前2组VAS差异无统计学意义;治疗后研究组为(3.63±1.36)分,对照组为(6.21±1.52)分,差异有统计学意义(P<0.05)。治疗前2组鼻内镜检查量化评分差异无统计学意义;治疗后研究组为(8.90±1.75)分,对照组为(12.85±2.59)分,差异有统计学意义(P<0.05)。结论鼻用激素明胶海绵对鼻窦炎术腔的迁延性炎症具有良好的疗效,但是远期疗效仍需进一步研究。

Objective To observe the efficacy of gelation sponge with intranasal corticosteroids （mometasone） on nasal mucosal persistent refractory inflammation after endoscopic sinus surgery. Methods From Septermber 2013 to October 2014, 25 cases with persistent refractory inflammation after endoscopic surgery were included in the study. After cleaning up the sinus cavity, 11 cases in research group were treated with gelation sponge with mometasone covering sinus cavity. In the first two weeks, it was performed twice a week, in the next two weeks, it was performed once a week. Fourteen cases in＇control group were only accepted cleaning up sinus cavity two times in four weeks. At the same time, two groups were all treated with conventional medicine. Visual analogue scale （VAS） and score of nasal endoscopy were recorded beefore and four weeks after the treatment. Results Before the treatment, both scores of VAS and nasal endoscopy were not statistically different. After the treatment, VAS and score of nasal endoscopy in the treatment group was 3.63 ± 1.36 and 8.90 ± 1.75 respectively, which were lower than those in the control group （6.21 ± 1.52 and 12.85 ± 2.59 respectively ） （P 〈 O. 05 ）. Conclusions The treatment of gelation sponge with mometasone was effective for nasal mucosal persistent refractory inflammation, further research was needed for long- term efficacy.