摘要
设计了一个直径为1 mm的新型植入式磁力驱动供药腔,该供药腔包括磁性薄膜、聚二甲基硅氧烷(PDMS)空腔、PDMS薄膜以及内径为0.4 mm的聚四氟乙烯(PTFE)导管构成,通过O2等离子处理工艺和键合形成空腔。将直流电源与铜线轴相连作为磁场源,通过其产生的磁场与磁性薄膜之间的磁力作用,磁性薄膜发生形变。当外部磁场开始工作时,通过改变电流大小控制药物供给量,磁性薄膜受到磁场的作用力对腔内的液体药物进行挤压,药物排出腔外。当外部磁场关闭后,磁性薄膜不再受到磁场的作用力,逐渐恢复原状,停止供药。经过测试,当磁感应强度达到100 mT时,供药系统的最大供药量为28.8μL。
A novel implantable drug supply cavity driven by magnetism was designed with the diameter of 1 mm. The drug supply cavity was composed of a magnetic film, polydimethylsiloxane （PDMS） cavity, PDMS film and polytetrafluoroethylene （PTFE） catheter with an inner diameter of 0.4 mm, and was formed through the 02 plasma treatment process and bonding process. The DC power source connected with the copper spool can be used as the mag- netic field source, and the magnetic film is deformed by the magnetic force between the magnetic field and the magnetic film. When the external magnetic field starts to work, the supply of the drug can be controlled by the current, and the magnetic film gets the force of magnetic field to extrude the liquid drug in the cavity, then the drug was sent out of the cavity. When the external magnetic field is closed, the magnetic film is no longer subject to the force of magnetic field, and gradually restores to the original state as well as stops the supply of drugs. According to the test result, when the magnetic induction intensity reaches 100 mT, the maximum dosage of the drug supply system is 28.8 μL.
出处
《微纳电子技术》
北大核心
2017年第12期829-834,共6页
Micronanoelectronic Technology
基金
国家自然科学基金资助项目(61471324)
