额叶梗死卒中后抑郁患者静息态功能MRI的局部一致性研究

Regional homogeneity alterations in patients with post-stroke depression： a resting-statefunctional MRI study

目的利用静息态功能磁共振成像（rs-fMRI）技术观察静息状态下额叶梗死卒中后抑郁（PSD）患者脑区局部一致性（ReHo）的变化特点。方法收集自2016年4月至2017年6月南方医科大学珠江医院康复科收治的12例额叶梗死PSD患者（PSD组）以及12例无PSD的额叶梗死患者（对照组）进行rs-fMRI扫描，以ReHo作为观测指标，分析PSD患者的脑功能特点。结果与对照组相比，PSD组患者ReHo增高的脑区有：右侧海马、左侧颞中回、右侧颞上回、右侧岛叶、右侧额下回、左侧扣带回、右侧中央后回、右侧额上回，差异均有统计学意义（P〈0．05，体素值≥10）；PSD组患者ReHo降低的脑区有：左侧小脑后叶、左侧小脑前叶、右侧楔前叶、右侧顶上小叶、右侧缘上回，差异均有统计学意义fP〈0．05，体素值≥10）。结论PSD患者ReHo异常变化的区域主要集中于边缘系统和右侧顶叶以及左侧小脑．并且涉及部分颞叶和部分右侧额叶。

Objective To describe the characteristics of regional homogeneity （ReHo） of brain in post-stroke depression （PSD） patients by resting-state functional magnetic resonance imaging （rs-fMRI）. Methods From April 2016 to June 2017, 12 frontal lobe stroke patients with PSD （PSD group） and 12 frontal lobe stroke patients without PSD （control group） were designed to scan by rs-fMRI. The ReHo maps were analyzed with paired t-test to compare the ReHo changes between the two groups and the cerebral function features of patients with PSD were analyzed. Results As compared with control group, the patients from PSD group showed significantly increased ReHo level in the right hippocampus, left transverse temporal gyms, right superior temporal gyms, right insula, fight inferior frontal gyms, left cingulate gyms, right inferior parietal lobule, right postcentral gyms, right precentral gyrus and right superior frontal gyrus, and significantly decreased ReHo levels in the left cerebellum posterior lobe, left cerebellum anterior lobe, left occipital lobe, right occipital lobe, right precuneus, right parietal lobe, right supramarginal gyms, and right superior parietal lobule （P〈0.05, cluster threshold 〉 10）. Conclusion Abnormal activities focus on limbic system, fight parietal lobe and left cerebellum in patients with PSD, and meanwhile, a part of temporal lobe and frontal lobe are also activated.