NLRP3炎性复合体在阿尔茨海默病中的研究进展

Recent advance in nod-like receptor protein 3 inflammasome and Alzheimer＇s disease

神经炎症反应是阿尔茨海默病（AD）的重要病理机制之一。研究证实，小胶质细胞核苷酸结合寡聚化结构域样受体3（NLRP3）炎性复合体的特异性激活通过多种机制参与AD的神经炎症过程．对于AD的发生、发展至关重要。本文围绕NLRP3炎性复合体在AD中的作用、机制以及NLRP3炎性复合体抑制剂的相关研究总结并报道如下。

Neuroinflammation plays a pivotal role in Alzheimer＇s disease （AD）. A growing number of studies proved that nod-like receptor protein 3 （NLRP3） inflammasome was involved in the neuroinflammation of AD through multiple mechanisms, which are crucial to the initiation and development of AD. In this paper, we will summarize the role ofNLRP3 inflammasome and its potential mechanism in AD pathogenesis, as well as NLRP3 infiammasome inhibitors.