对比红霉素与阿奇霉素治疗肺炎支原体感染的临床效果

Comparison of Erythromycin and Azithromycin in the Treatment of Mycoplasma Pneumoniae Infection

目的:比较红霉素与阿奇霉素治疗肺炎支原体感染的临床效果。方法:将66例肺炎支原体感染患儿随机分为A、B组,每组33例,A组在常规治疗基础上加用红霉素,B组在常规治疗基础上加用阿奇霉素,治疗周期均为3~4周,治疗结束后评定疗效及不良反应。结果:A组临床总有效率为90.91%,显著优于B组的72.73%,差异有统计学意义(P<0.05);A组患儿住院时间,咳嗽减轻、体温恢复正常、肺部啰音消失时间均显著短于B组,差异均有统计学意义(P<0.05),但不良反应发生率显著高于B组,差异有统计学意义(P<0.05)。结论:红霉素治疗肺炎支原体感染患儿效果较阿奇霉素显著,可以缩短患儿住院时间和临床症状消失时间,但不良反应发生率相对较高,临床使用需视具体情况综合考虑。

Objective： To compare the clinical efficacy of erythromyciu and azithromycin in the treatment of mycoplasma pneumoniae infection. Method： 66 cases of mycoplasma pneumonia in children were randomly divided into two groups（group A and group B）, 33 cases in each group.The cases in the group A were treated with erythromycin, and the cases in the group B were treated with azithromycin.The course of treatment was 3-4 weeks, the efficacy and adverse reactions were evaluated after treatment.Result： The clinical total effective rate in the group A was 90.91%, which was significantly better than that（72.73%） in the group B（P〈0.05）.The hospitalization time, the time of relieve cough, body temperature returned to normal, pulmonary rales disappeared in the group A were significantly shorter than those of group B（P〈0.05）.The incidence of adverse reactions in the group A was significantly higher than that of group B（P〈0.05）.Conclusion： Erythromycin in the treatment of mycoplasma pneumoniae infection in children has significant effect, can shorten the time of hospitalization and clinical symptoms disappeared time, but the adverse reaction rate is relatively high, the clinical use of erythromycin should be considered by the specific situation.