Krüppel样因子7(KLF7)生物学功能研究进展

Advance in Biological Function of Krüppel-like Factor 7(KLF7)

Krüppel样因子7(Krüppel-like factor 7,KLF7)是Sp1样或Krüppel样转录因子家族(specificity protein/Krüppel-like factor,SP/KLF)成员,在多种生物学过程中发挥重要作用,该基因完全敲除小鼠出生时大部分死亡.KLF7是肥胖症、Ⅱ型糖尿病、心血管疾病、癌症、面部发育异常、氧化磷酸化缺陷和Ⅰ型自身免疫性胰腺炎等疾病的相关基因.功能分析显示,KLF7是神经系统发育和脂肪形成的关键因子,同时也在肌肉再生和造血作用中发挥功能.在SP/KLF家族中,KLF7研究相对较少,大部分作用机制尚不清楚.本文从结构和功能方面详述了KLF7的最新研究进展,为其和KLFs家族深入研究提供重要的科学依据.

Kruppel-like factor 7（KLF7） is one of the members of specificity protein/krtippel-like factor（SP/KLF） transcription factor family, which play crucial roles in diverse arrays of biological processes including cell stemness, proliferation, differentiation, apoptosis, and energy metabolism. KlfT-null mice died within the first 3 days of life due to abomoality in nervous system. Genetics and epigenetics studies showed that KLF7 is associated with obesity, type 2 diabetes, cardiovascular disease, leukemia, diffuse gastric cancer, rectal adenocarcinoma, face development disordered, oxidative phosphorylation deficient, and type 1 autoimmune pancreatitis. Functional analysis revealed KLF7 is a key regulator of neurogenesis and neuron development, and inhibit preadipocyte differentiation and promote proliferation. In addition, KLF7 mediates muscle stem cell quiescence and suppresses hematopoietic stem and progenitor cell function. However, among the SP/KLF family members, the roles of KLF7 in these biological processes are only beginning to be understood, and most of the mechanisms remain unclear. This review summarizes the latest research progress of KLF7 in the structure and fuctions, and highlights its importance in tissue development, cell proliferation and differentiation, and disease generation.