启东市肝癌患者家族成员乙型肝炎病毒感染状况调查

Investigation of HBV infection in members of Qidong liver cancer family

目的了解启东市乙型肝炎病毒表面抗原(HBsAg)阳性肝癌患者的家族成员乙型肝炎病毒(hepatitis B virus,HBV)感染状况和特点。方法以242例HBsAg阳性肝癌患者为先证者,对其家族成员(父母、同胞、子女)进行调查,并采集其静脉血检测HBV血清学指标,对家族成员中HBV感染状况和特点进行统计学分析。结果 825名家族成员HBsAg阳性率39.76%,显著高于当地队列人群(10.92%)和一般人群(8.00%)(P<0.001)。男性、女性的HBsAg阳性率分别为39.17%和40.16%,差异无统计学意义(P>0.05)。父母、同胞、子女的HBsAg阳性率分别为16.33%、46.37%、35.50%,组间比较,差异均有统计学意义(P<0.01)。先证者父亲与母亲、兄弟与姐妹、儿子与女儿的HBsAg阳性率比较,差异均无统计学意义(P>0.05)。女性先证者父母、同胞的HBsAg阳性率与男性先证者的父母、同胞相比,差异无统计学意义(P>0.05),但子女的HBsAg阳性率是男性先证者子女的3.52倍(P<0.001)。结论 HBsAg阳性在肝癌家族中有聚集现象,性别可能与HBV感染无关,家族中母婴传播效应显著大于父婴传播。

Objective To study the status and characteristics of hepatitis B virus （HBV） infection in family mem- bers of HBsAg-positive liver cancer patients in Qidong. Methods Eight hundred and twenty-five family members （par- ents, compatriots, children） of 242 HBsAg-positive patients with liver cancer were investigated, and their venous blood was collected to detect HBV serological indexes. The status and characteristics of HBV infection in family members were statistically analyzed. Results The HBsAg-positive rate of family members was 39.76% , higher than those of local co- hort （ 10.92% ） and general population （8.00%）, the difference was statistical significant （P 〈 0. 001 ）. The positive rates of HBsAg in males and females were 39.17% and 40.16% , respectively, and the difference was not statistically significant （P 〉 0.05）. The positive rates of H BsAg in parents, compatriots, and children were 16.33% , 35.5% and 46.37% , respectively, the difference among three groups was statistically significant （P 〈 0. O1 ）. There was no statisti- cally significant difference in the positive rate of HBsAg between fathers and mothers, brothers and sisters, sons and daughters （P 〉 0. 05）. The difference of HBsAg-positive rate in parents and compatriots between female and male probands were not statistically significant （ P 〉 0.05 ）, but the positive rate of HBsAg in children of female probands was 3.52 times than that of the children of the male probands （P 〈 0. 001 ）. Conclusion I-IBsAg-positive in the hepatoma family has aggregation phenomenon, but gender may be unrelated with HBV infection. The effect of mother-to-child transmission is significantly greater than father-to-child transmission in the family.