蔗糖铁注射剂在关节置换术患者围术期的应用效果

Effect of iron sucrose injection on perioperative patients with joint replacement

目的 分析蔗糖铁注射剂在关节置换术患者围术期的应用效果。方法 收集2016年1—12月于上海市第一人民医院行关节置换术的63例患者的病历资料进行回顾性分析。按术后是否使用铁剂分为对照组（35例）和用药组（28例），对照组患者住院期间未使用铁剂，用药组患者在术后按照缺铁情况给予蔗糖铁注射液静脉滴注。比较2组患者手术前及出院时C反应蛋白水平（CRP）和住院天数，分析蔗糖铁注射液使用剂量与患者CRP水平及住院天数之间的相关性。结果 出院时用药组CRP水平低于对照组［（47±19）mg/L比（63±33）mg/L］，差异有统计学意义（P〈0.05）；用药组患者住院天数少于对照组［（12±3）d比（17±5）d］，差异有统计学意义（P〈0.01）。患者补铁剂量与出院时CRP水平及住院天数均呈负相关（r=-0.463、-0.480，P〈0.05）。结论 铁剂的合理使用可降低关节置换术患者围术期CRP水平，减少患者住院天数。

Objective To analyze the effect of iron sucrose injection on perioperative patients with joint replacement. Methods Clinical data of 63 patients who had joint replacement in Shanghai General Hospital from January to December 2016 were collected for retrospective analysis; 28 patients had intravenous administration of iron sucrose injection（iron sucrose group）; 35 patients was not treated with iron sucrose（control group）. Dosage of iron sucrose, level of C-reactive protein（CRP） and length of hospital stay were analyzed. Results The level of CRP on discharge in iron sucrose group was significantly lower than that in control group［（47±19）mg/L vs （63±33）mg/L］（P＜0.05）. The length of hospital stay in iron sucrose group was significantly shorter than that in control group［（12±3）d vs （17±5）d］（P＜0.01）. The dosage of iron sucrose was negatively correlated with level of CRP on discharge and length of hospital stay（r＝－0.463, －0.480; P＜0.05）. Conclusion Reasonable use of iron sucrose injection after joint replacement reduces CRP level and hospital day.