生脉液的制法和动物实验的效果

The effect of two batches of Sheng-mai liquid on rats

本文对生脉散分别采用乙醇回流+水煎酒沉法和中药传统的水煎煮法提取有效成分,制备生脉心肌灌注液,实验用Wister大鼠,按Langendorff氏方法建立灌注装置,动物分有氧灌注组,缺氧灌注组和缺氧+生脉液(水、醇法)组,对实验动物心肌损害模型分别观察生脉液对心肌超微结构的变化。实验显示,生脉液能显著保护缺氧缺血心肌细胞,而以水煎煮,生脉灌注液对心肌缺氧的防治更为明显,然此法杂质难以除尽,不宜久贮,提示生脉散有效成分的提取方法值得研究。

The myocardial cells can be protected frominjury in oxygen-deficiency and ischemic conditionby Sheng-mai liquid, which is an extract of Gincengroot. Radix Ophiopogonis and Schizandra fruits. The effect of water extract prepared by Chinesetraditional method is better than that of alcohol-water extract.