新辅助化疗对局部晚期乳腺癌治疗的效果研究

The Study of the Effect on the Treatment for the Local Advanced Breast Cancer by Neoadjuvant Chemotherapy

目的:探讨局部晚期乳腺癌术前化疗的临床意义。方法:对66例局部晚期乳腺癌采用新辅助化疗CAF(或CEF)方案,TA(或TC)方案共(3~4)个周期,分别测量化疗前、后肿瘤大小的变化,评价疗效。择期行根治手术或保乳手术、局部根治性放疗、术后个体化综合治疗。结果:新辅助化疗后66例中,临床完全缓解(CR)4例,部分缓解(PR)43例,无效(NC)18例,进展(PD)1例,总有效(CR+PR)率71.06%。未发生严重毒副反应。结论:局部晚期乳腺癌新辅助化疗具有降低肿瘤分期,增加根治和保乳手术机会,指导术后化疗方案选择,消灭全身亚临床转移病灶,提示病情预后,提高5年生存率的临床意义。

Objective：This paper explored the clinical significance of preoperative neoadjuvant chemotherapy for locally advanced breast cancer. Methods. The CAF/CEF chemotherapy was used in 66 patients with advanced breast cancer. The TA/TC therapy was used for（3-4）cycles. The changes of tumor size were measured before and after the chemotherapy, then they were conducted by selective radical surgery or breast conserving surgery, local radical radiotherapy,and postoperative individualized comprehensive treat- ment.Results： In the 66 cases of neoadjuvant chemotherapy, there were 4 cases of complete remission （CR）, 43 cases of partial remission （PR）, 18 cases of no effect（NC）, 1 case of progress （PD）.The total effective rate（CR＋PR）was 71.06%. No serious side effects were occurred.Conclusions. Neoadjuvant chemotherapy has the function to reduce tumor staging, increase radical and breast conserving surgery, and it can also guide the choice of postoperative chemotherapy, and eliminate systemic subclinical metastases, which prompt the prognosis and improve the patient＇s 5--year survival rate for patients with local advanced breast cancer.