二氧化碳激光联合中药坐浴治疗妊娠期生殖器尖锐湿疣疗效观察

Observation on efficacy of carbon dioxide laser combined with traditional Chinese medicine bathing in the treatment of genital warts during pregnancy

目的观察二氧化碳激光联合中药坐浴治疗妊娠期生殖器尖锐湿疣的临床效果。方法 66例女性妊娠期生殖器尖锐湿疣患者,随机分为治疗组和对照组,每组33例。两组患者均首先给予二氧化碳激光清除疣体,创面结痂后治疗组给予中药外洗坐浴联合阿昔洛韦乳膏外用治疗,对照组仅给予阿昔洛韦乳膏外用治疗。观察并比较两组患者术后3个月治疗总有效率、复发率,并观察继续妊娠患者的妊娠结局。结果 66例患者中有8例自动结束妊娠,其余58例孕妇均选择剖宫产结束分娩,产程基本顺利,均为单胎,无产科并发症发生,58例新生儿均为足月分娩存活,无胎儿宫内发育迟缓、新生儿喉乳头状、生殖器疣及肛门疣等。治疗组患者治疗总有效率为90.9%,明显高于对照组的69.7%,差异具有统计学意义(P<0.05);治疗组患者复发率为9.1%,低于对照组的33.3%,差异具有统计学意义(P<0.05)。结论二氧化碳激光联合中药坐浴治疗女性妊娠期生殖器尖锐湿疣是一种安全有效且复发率低的治疗方法 ,值得推广。

Objective To observe the clinical treatment effect of carbon dioxide laser combined with traditional Chinese medicine bathing in the treatment of genital warts during pregnancy. Methods A total of 66 female patients with genital warts during pregnancy were randomly divided into treatment group and control group, with 33 cases in each group. Both groups received carbon dioxide laser for warts removal, and after wound scab, the treatment group was treated with traditional Chinese medicine bathing and external application of acic]ovir ointment. Observation and comparison were made on total treatment effective rate and recurrence rate in＇postoperative 3 months and the pregnancy outcome in patients with continuing pregnancy between two groups. Results In 66 cases, 8 cases finished the pregnancy automatically, and the other 58 cases complete the delivery by cesarean section. The delivery process was basically smooth with no occurrence of obstetric complications and all were singleton. 58 cases of newborns were full-term childbirth survival, with no fetal intrauterine growth retardation, neonatal laryngeal papillary, genital warts and anal warts. The treatment group had obviously higher total treatment effective rate as 90.9% than 69.7% in the control group, and the difference was statistically significant （P〈0.05）. The treatment group had lower recurrence rate as 9.1% than 33.3% in the control group, and the difference was statistically significant （/9〈0.05）. Conclusion Combination of carbon dioxide laser and traditional Chinese medicine bathing is a safe and effective treatment treatment method in treating female genital warts during pregnancy With low recurrence rate. It is worth promoting.