长期高效抗逆转录病毒治疗后的代谢异常改变

Altered metabolism after long-term highly active antiretroviral therapy

HAART的应用大大降低了艾滋病患者的死亡率,但同时也增加了各种不良反应,其中远期不良反应主要与代谢异常改变有关,如脂肪重新分布、胰岛素抵抗、血脂异常、骨质疏松等,不仅大大增加了患者发生心血管疾病的风险,对肝肾功能也有不同程度的影响.HAART因耗时长、进展慢等导致其原因所引起的不良反应不易被察觉,也未得到足够的重视.本文对长期HAART后出现的代谢改变及其机制作一综述.

Since the application of HAART,the mortality rate of people with AIDS has been greatly reduced.However,side effects appear,among which some long-term adverse reactions are mainly associated with metabolic changes,such as fat redistribution,insulin resistance,dyslipidemia and osteoporosis.These adverse reactions increase the risk of cardiovascular diseases and influence the function of liver and kidney.Because of the timeconsuming and slow progress,these adverse reactions are often concealed.The related factors and mechanisms of the metabolic changes after long-term HAART are reviewed in this article.