NF—κB信号途径在COPD中的研究进展

Progress of NF-κB signaling pathway in COPD

核转录因子κB（nuclearfactorofkappaB，NF—κB）是一种广泛存在的核转录调节蛋白，它调控着与炎症、免疫、细胞增殖、分化和凋亡相关的多种基因的表达。NF-κB信号途径的激活与COPD的发生发展密切相关。抑制NF—κB信号途径的激活成为治疗COPD的新靶点，目前已发现多种药物通过干预NF—κB信号途径的不同位点来抑制其激活，从而可用于治疗COPD。本文综述了NF-κB及其信号途径的激活与抑制、NF-κB在COPD发病机制中的作用及通过阻断NF—κB信号途径来治疗COPD的各类药物。

Nuclear factor of kappa B （NF-κB） is a kind of widespread nuclear transcription regulatory proteins, and it regulates the expression of multiple genes, including inflammation, immunity, cell proliferation, differentiation and apoptosis. The activation of NF-κB signaling pathway is closely related to the genesis and development of COPD. Inhibiting the activating of NF-κB signaling pathways become the new target for treatment of COPD. Now it has been found that a variety of drugs can inhibit the activating of NF-κB signaling pathways by intervening in different sites of NF-κB signaling pathway, which can be used in the treatment of COPD. This paper reviews the NF-κB and the activation and inhibition of its signal pathway, the pathogenesis of NF-κB signal pathway in COPD, and the treatment of various drugs in COPD by blocking NF-κB signaling pathways.