间充质干细胞融合在肿瘤转移中的研究进展

Research progress of mesenchymal stem cell fusion in the tumor metastasis

侵袭转移是恶性肿瘤的基本特征和重要标志,也是导致肿瘤患者死亡的主要原因。上皮-间质转化(epithelial-mesenchymal transition,EMT)是肿瘤侵袭转移的首要步骤。研究表明,细胞融合是肿瘤发生转移过程中的常见现象之一。间充质干细胞(mesenchymal stem cell,MSC)是细胞融合中广泛涉及的一种重要细胞,并通过细胞融合在肿瘤发生转移过程中发挥重要作用。本文主要综述了间充质干细胞与肿瘤细胞融合在肿瘤转移中的最新研究进展,其机制的阐明有可能为肿瘤治疗提供新的策略。

Invasion and metastasis are the basic characteristics and important symbols of malignant tumors,which are also the main causes of death in patients with cancer.Epithelial-mesenchymal transition（EMT） is an essential step during the process of tumor invasion and metastasis.In the process of tumor metastasis,lots of studies have shown that cell fusion is one of the common phenomena.Mesenchymal stem cell（MSC） is an important fusogenic candidate and plays a critical role in tumor metastasis through cell fusion.This review summarizes the recent research progress of cell fusion between MSCs and malignant cells in the tumor metastasis.The elucidation of its mechanisms may provide a new strategy for tumor therapy.