健康体检人群高尿酸血症患病情况及其相关因素分析

Analysis of the prevalence and related factors of hyperuricemia in physical examination people

目的探索健康体检人群高尿酸血症的检出率,并分析其相关危险因素。方法选取2015年7月至2016年12月来本院体检中心参加体检年龄≥18岁人群作为研究对象,采用自行设计调查问卷对其进行调查,并进行体格及实验室检查,获取高尿酸血症检出率,并分析其相关影响因素。结果 10138位健康体检者中,共检出高尿酸血症2354人,检出率为23.22%,且男性检出率(29.43%)明显高于女性(18.97%),高年龄组高于低年龄组。Logistic回归结果显示,性别、年龄、BMI、SBP、DBP、TC、TG、LDL-C、Glu、饮酒、摄入海鲜、高血压病史、高血脂病史、代谢综合征病史与高尿酸血症呈正相关,而HDL-C、锻炼、饮茶、新鲜水果和豆制品摄入与之呈负相关。结论健康体检者高尿酸血症检出率较高,并且影响高尿酸血症的影响因素众多,应积极避免不利因素,加强保护因素,以期降低高尿酸血症患病率。

Objective To explore the prevalence of hyperuricemia in healthy physical examination people,and understand its related factors. Methods In this study,we recruited the healthy physical examination people in our hospital physical examination center as subjects from July 2015 to December 2016. All the subjects were more than 18 years old. A self-designed questionnaire was used to investigate the characters of subjects,and the physical and laboratory examinations were carried out to obtain the detection rate of hyperuricemia. Finally,we analyzed the related factors of hyperuricemia. Results Of all the 10,138 healthy subjects,2,354 were detected hyperuricemia,and the detection rate was 23.22%. Herein,the detection rate of male（ 29.43%） was significantly higher than that of women（ 18.97%）,and the higher age group was higher than that of the low age group. Logistic regression analysis showed that the following factors was positively related to hyperuricemia： gender,age,BMI,SBP,DBP,TC,TG,LDL-C,Glu,drinking,intake of seafood,the history of hypertension,hyperlipidemia,and metabolic syndrome; however,HDL-C,exercise,tea,fresh fruit and soy products intake had negative correlation with hyperuricemia.Conclusions The rate of hyperuricemia is high in health examination,and the influencing factors of hyperuricemia are numerous. We should avoid the negative factors and strengthen the protective factors to reduce the prevalence of hyperuricemia.