双歧杆菌三联活菌肠溶胶囊对小儿肺炎继发腹泻的预防效果分析

Preventive effect analysis of bifidobacterium triple live mushroom enteric-coated capsules on secondary diarrhea in children with pneumonia

目的探讨双歧杆菌三联活菌肠溶胶囊对小儿肺炎继发腹泻的预防效果。方法 150例小儿肺炎患儿,随机分成对照组和观察组,每组75例。对照组给予常规抗生素治疗,观察组在对照组基础上加用双歧杆菌三联活菌肠溶胶囊治疗,比较两组临床腹泻发生率、腹泻程度、不良反应、症状体征缓解时间及治愈时间。结果观察组腹泻发生率为13.33%,低于对照组的77.33%,差异有统计学意义(P<0.01)。观察组无腹泻患儿比例高于对照组,轻度腹泻、重度腹泻发生率均显著低于对照组,差异有统计学意义(P<0.01)。观察组腹泻缓解时间、呕吐缓解时间、退热时间及治愈时间均显著短于对照组,差异有统计学意义(P<0.01)。两组患儿治疗过程中均无明显不良反应发生。结论在抗生素治疗基础上联合双歧杆菌三联活菌肠溶胶囊治疗小儿肺炎可有效减少腹泻的发生,值得临床推广应用。

Objective To discuss the preventive effect analysis of bifidobacterium triple live mushroom enteric-coated capsules on secondary diarrhea in children with pneumonia. Methods A total of 150 children with pneumonia were randomly divided into control group and observation group, with 75 cases in each group. The control group was treated with conventional antibiotics, and the observation group was treated with bifidobacterium triple live mushroom enteric-coated capsules on the basis of the control group. Comparison were made on incidence of diarrhea, degree of diarrhea, adverse reactions, symptoms and signs remission time and cure time between two groups. Results The observation group had lower diarrhea rate as 13.33% than 77.33% in the control group, and the difference was statistically significant（P0.01）. The observation group had higher proportion of children without diarrhea than the control group, and obviously lower mild and severe diarrhea rate than the control group. Their difference was statistically significant（P0.01）. The observation group had obviously shorter diarrhea remission time, vomiting remission time, fever time and cure time than the control group, and their difference was statistically significant（P0.01）. Both groups had no obvious adverse reactions during treatment. Conclusion On the basis of antibiotic therapy, bifidobacterium triple live mushroom capsules in children with pneumonia can effectively reduce the incidence of diarrhea, worthy of clinical application.