血清SCC与CysC在慢性肾脏病患者中的变化及临床价值

Change and clinical value of serum SCC and CysC in patients with chronic kidney disease

目的探讨血清鳞状细胞癌抗原(SCC)与胱抑素C(CysC)在慢性肾脏病(CKD)患者的变化及临床价值。方法选取110例CKD患者(研究组)及同期100例健康体检者(对照组)作为研究对象,按照肾小球滤过率将CKD患者分为CKD1期25例,CKD2期22例,CKD3期26例,CKD4期18例,CKD5期19例;检测各组研究对象的血清SCC,CysC、肌酐和尿微量白蛋白(mALB)水平,分析CKD患者血清SCC与CysC的变化及其相关性。结果研究组中患者血清SCC、CysC、肌酐及mALB水平显著高于对照组,差异均有统计学意义(P<0.05),并且CKD患者血清SCC、CysC、肌酐及mALB水平随着CKD分期的增加而明显升高,各分期间差异均具有统计学意义(P<0.05);血清SCC水平与CysC、肌酐及mALB均呈正相关(r=0.764,r=0.692,r=0.655,P<0.05)。结论 CKD患者血清SCC、CysC、肌酐及mALB水平均显著升高,并随着CKD分期的增加而增加,并且血清SCC与CysC、肌酐及mALB均成正相关,因此对CKD的诊断有重要的临床价值。

Objective To explore changes of serum squamous cell carcinoma antigen（ SCC） and cystatin C（ CysC）concentration of patients with chronic kidney disease（ CKD） and their clinical value. Methods Totally 110 patients with CKD（ research group） were selected and 100 cases of healthy physical examination（ control group） as the research object,the CKD patients were divided into the stage 1 group（ n = 25）,stage 2 group（ n = 22）,stage 3 group（ n = 26）,stage 4 group（ n = 18） and stage 5 group（ n = 19） by GFR. The levels of serum SCC,CysC,createinine and the urine trace albumin（ mALB） in the research group and control group were detected,the changes of serum SCC and CysC were analyzed and the correlation between them in CKD patients were analyzed. Results The levels of serum SCC,CysC,creatinine and mALB in the research group were significantly higher than those in the control group（ P〈0. 05）; The levels of serum SCC,CysC,creatinine and mALB for patients were significantly increased with the increase of CKD stage increased（ P〈0. 05）; the positive correlation were demonstrated among serum SCC and CysC,creatinine,mALB（ r = 0. 764,r = 0. 692,r = 0. 655,P〈0. 05）. Conclusions The levels of serum SCC,CysC,creatinine and mALB in CKD patients were increased significantly,which were significantly increased with the increase of CKD stage increased; And the levels of serum SCC,CysC,creatinine and mALB for patients were significantly increased with the increase of CKD stage increased,which the diagnosis of chronic kidney disease（ CKD） has important clinical value.