适配子在肿瘤干细胞研究中的应用

Application of aptamer in the study of cancer stem cells

肿瘤干细胞具有自我更新和多向分化潜能，在肿瘤生成、转移、复发和放化疗抗性等方面起着重要作用，是近年来肿瘤研究的热点。适配子是小分子寡核苷酸，具有极强的靶向性和亲和力，是肿瘤诊断和治疗的新型核酸分子。目前利用适配子进行肿瘤干细胞的诊断和治疗的研究越来越多，为肿瘤的诊断和治疗提供新的研究工具。

Cancer stem cells have selfrenewal and multilineage differentiation potentials, which play important roles in tumorigenesis, metastasis, recurrence and resistance to chemical therapy and radiotherapy, and so on. It is the hotspot of tumor research recently. Aptamer is a small molecular oligonucleotide with high targeting ability and affinity, which is a new type of nucleic acid in the diagnosis and treatment of cancer. Now more and more research is being done on the aptamer is applied in the diagnosis and treatment of cancer stem cells, which provides a new research tool for the diagnosis and treatment of cancer stem cells.