IL-25与变态反应性气道炎症

IL-25 and allergic airway inflammation

变态反应性气道炎症主要表现为气道局部CD4^+T细胞和嗜酸性粒细胞浸润、黏液分泌增多、气道高反应性及气道重塑。IL-25是IL-17家族成员之一,通过与其受体结合诱发和加重Th2细胞因子介导的气道炎症,导致IL-4、IL-5和IL-13等Th2炎症因子分泌增加以及嗜酸性粒细胞局部浸润,从而导致气道高反应性和气道损伤。本文对IL-25在变态反应性气道炎症中的重要作用作一综述。

Allergic airway inflammation is manifested as infiltration of CD4＋ T cells and eosinophils in the airway, increased secretion of mucus, airway hyper-reactivity and airway remodeling. IL-25 is a member of the IL-17 family, which can promote and exacerbate Th2 cytokine-mediated airway inflammation after binding to its receptor IL-17 RB. The increased IL-25 can induce the secretion of Th2 cytokines, including IL-4, IL-5 and IL-13, which may result in the local infiltration of eosinophils, airway hyperreactivity and therefore the injury of airway. As IL-25 plays an important role in allergic airway inflammation, the present paper would focus on the relationship between IL-25 and allergic airway inflammation.