过敏性哮喘患者穴位贴敷后诱发的接触性皮炎皮损处EOS浸润特点

EOS Infiltration Characteristics of Contact Dermatitis Induced by Acupoint Application in Allergic Asthma Patients

目的:分析过敏性哮喘患者穴位贴敷后诱发的接触性皮炎皮损处嗜酸性粒细胞(eosinophils,EOS)浸润特点。方法:13例穴位贴敷治疗后诱发接触性皮炎并进行皮损处活检患者,按有无过敏性哮喘,分为过敏性哮喘组8例,非过敏性哮喘组5例。观察指标:(1)两组皮损处EOS聚集部位及数目的差异性;(2)两组真皮血管周围EOS病理结果分级的差异性。(3)两组表皮水泡液常规中EOS占总细胞数目百分比的差异性。结果:过敏性哮喘组真皮血管周围平均EOS数目(16.75±8.54)HP^(-1)明显高于无过敏史组(2.80±1.45)HP^(-1)。(1)过敏性哮喘组真皮血管周围EOS病理分级程度在Ⅲ、Ⅳ级(4例)重于非过敏性哮喘组(0例)。(2)过敏性哮喘组表皮水疱液EOS占总细胞百分比(45.3±17.1)%明显高于非过敏性哮喘组(12.7±4.4)%。结论:过敏性哮喘患者穴位贴敷后诱发的接触性皮炎皮损处EOS浸润程度增加。

Objective： To analyze the eosinophils（ EOS） infiltration characteristics in patients with allergic asthma after acupoint application. Methods： 13 patients with contact dermatitis induced by acupoint application were divided into allergic asthma group（ 8 patients） and non-allergic asthma group（ 5 patients）. The differences of the site and number of EOS at skin lesions,the EOS pathological grade differences and the percentage of EOS in the total number of cells in the two groups were observed. Results： The average number of EOS（ 16. 75 ± 8. 54） · HP^-1 in allergic asthma group was significantly higher than that in non-allergic group（ 2. 80 ± 1. 45） HP^-1. The degree of EOS pathology in the perihematoma of allergic asthma group was higher than that in non-allergic asthma group（ 0 cases） in grade Ⅲ and Ⅳ（ 4 cases）. The percentage of total EOS in the epidermal blister fluid of the allergic asthma group was significantly higher than that in the non-allergic asthma group（ 12. 7 ± 4. 4） %. Conclusion： The degree of EOS infiltration of contact dermatitis induced by acupoint application in allergic asthma patients increased.