从筋疽理论论治糖尿病足坏疽临床研究

Discussion on Treatment Diabetic Foot Gangrene from Tendon-gangrene Theory

目的:观察从筋疽理论论治糖尿病足坏疽的临床疗效。方法:通过574例糖尿病足坏疽患者病例资料回顾性总结,分析其一般资料、临床疗效、炎症指标及糖代谢指标。结果:574例患者保肢成功率99.13%;治疗后患者C反应蛋白(Creactive protein,CRP)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、白细胞介素6(interleukin 6,IL-6)与治疗前比较,差异均有统计学意义(P<0.01);治疗后患者空腹血糖(fasting blood-glucose,FPG)、C肽、糖化血红蛋白(glycosylated hemoglobin,Hb A1c)与治疗前比较,差异均有统计学意义(P<0.05)。结论:从筋疽理论论治糖尿病足坏疽的临床疗效满意,可显著降低患者炎症因子水平和血糖水平。

Objective： To observe the clinical curative effect of Tendon-gangrene theory on diabetic foot gangrene. Methods： A total of 574 patients with diabetic foot gangrene were retrospectively reviewed. The general data,clinical efficacy,inflammation index and glucose metabolism were analyzed. Results： The success rate of limb salvage was 99. 13% in 574 patients. C-reactive protein（ CRP）,tumor necrosis factor α（ TNF-α）,interleukin 6 were compared before and after treatment,the difference was statistically significant（ P〈0. 01）. After treatment,fasting blood glucose（ FPG）,C-peptide,glycosylated hemoglobin（ Hb A1 c） were significantly higher than those before treatment（ P〈0. 01）,and the difference was statistically significant（ P〈0. 01）. Conclusion： The clinical curative effect of diabetic gangrene based on the theory of gangrene is significant,with which can significantly reduce the level of inflammatory factors and blood glucose.