中药调周法治疗PCOS不孕症疗效的Meta分析

A Meta-analysis of Outcomes of Menstrual Cycle-regulating Therapy in Infertile Women with PCOS

目的:评估调周法单独或联合COS对改善PCOS生殖障碍的疗效。方法:利用Review Manager系统回顾和荟萃分析调周法治疗PCOS不孕症的随机对照试验研究(Randomized Controlled Trials,RCTs)文献。结果:调周法+COS vs COS:前者临床妊娠率、排卵率、排卵前子宫内膜厚度、总有效率均显著升高,OHSS发生率显著下降,但两者双胎妊娠率、LUFS率、未启动周期率比较差异无统计学意义;调周法vs COS:前者总有效率升高,两者排卵率比较差异无统计学意义。结论:中药调周法可有效改善PCOS生殖障碍,提高COS周期临床妊娠率与排卵率,增加排卵前子宫内膜厚度,降低OHSS发生。

Objective：To evaluate the efficacy of menstrual cycle-regulating therapy individually or combined with COS for the treatment of reproductive disorder PCOS. Methods ： Using the review manager software to make a system-review and meta-analysis of randomized controlled trials （RCTs） for the infertility of PCOS by menstrual cycle-regulating therapy. Results： Menstrual cycle-regulating therapy ＋ COS vs COS： For the former, the clinical pregnancy rate, ovulation rate, endometrial thickness preovulatory and total effective rate were significantly increased, with a significant decline of OHSS incidence. Moreover, there was no significant difference in twin pregnancy rate, LUFS rate, and follicular dysplasia rate between the two groups; Menstrual cycle-regulating therapy vs COS： A increased total effective rate of the former was shown, but there was no significant difference in ovulation rate. Conclusion： Menstrual cycle-regulating therapy could effectively improve PCOS reproduction inability and lift the clinical pregnancy rate and ovulation rate, simultaneously thicken endometrium and reduce the incidence of OHSS.