肠道功能紊乱与慢性肾脏病

The intestinal microbiota,intestinal epithelia barrier and chronic kidney disease

越来越多的研究表明,慢性肾脏病(CKD)患者普遍存在炎症反应,且炎症反应可加快CKD的进展。多种因素参与了CKD介导的全身炎症反应及氧化应激反应。近期有研究发现肠道菌群的改变及肠黏膜上皮屏障功能失调与CKD有密切联系。CKD患者肠道菌群的种类及数量常发生改变,肠黏膜上皮细胞的紧密连接受损,肠道渗透压升高,毒素进入血液,引起全身炎症反应及氧化应激反应,从而导致CKD进展。本文就肠道菌群及肠黏膜上皮屏障功能与CKD关系作一综述。

There is increasing evidence pointing to that inflammation is a constant feature and a major mediator of the progression of chronic kidney disease（ CKD）. Many factors of CKD-induced systemic inflammation and oxidative stress have been explored. Recently,some studies have revealed the relationship between CKD and the dysfunction of intestinal microbiota and the impairment of intestinal epithelia barrier. Significant changes in the composition and function of intestinal bacterial flora are always found in CKD patients,as well as the impairment of the epithelia tight junction. And then,the increased intestinal permeability leads to the uremic toxins transferring to the circulation and systemic inflammation and oxidative stress,which causes the progress of CKD. Here,we will discuss the relationship between intestinal microbiota,intestinal epithelia barrier and CKD.