脾多肽注射液对直肠癌患者免疫功能及炎症反应的影响

Effects of lienal polypeptide injection on immune function and inflammatory reaction of patients with rectal cancer

目的探讨脾多肽注射液对直肠癌患者免疫功能及炎症反应的影响。方法选取2014年11月至2016年4月间内江市市中区人民医院收治的96例直肠癌患者,采用随机数表法分为观察组与对照组,每组48例。观察组患者在亚叶酸钙+5-氟尿嘧啶+伊立替康化疗方案基础上加用脾多肽注射液治疗,对照组患者给予亚叶酸钙+5-氟尿嘧啶+伊立替康化疗方案治疗。比较两组患者的免疫功能、炎症反应、临床疗效及不良反应。结果治疗前,两组患者的免疫功能指标CD3^+、CD4^+、CD8^+及自然杀伤细胞水平比较,差异无统计学意义(P>0.05)。治疗后,两组患者的免疫功能指标CD3^+、CD4^+及自然杀伤细胞水平均显著高于治疗前,CD8^+水平则明显低治疗前,且观察组患者治疗后的免疫功能指标CD3^+、CD4^+及自然杀伤细胞水平均显著高于对照组患者,而CD8^+水平则明显低于对照组患者,差异均有统计学意义(均P<0.01)。治疗前,两组患者的可溶性白细胞介素-2受体及白细胞介素-8水平比较,差异无统计学意义(P>0.05)。治疗后,两组患者的可溶性白细胞介素-2受体及白细胞介素-8水平均明显低于治疗前,且观察组患者治疗后的可溶性白细胞介素-2受体及白细胞介素-8水平均显著低于对照组患者,差异均有统计学意义(均P<0.01)。观察组患者的治疗有效率为79.2%,明显高于对照组的54.2%,差异有统计学意义(P<0.01)。观察组患者的骨髓抑制、肝肾功能异常、消化道反应及口腔黏膜炎的发生率均显著低于对照组患者,差异均有统计学意义(均P<0.01)。结论脾多肽注射液可有效改善直肠癌患者的免疫功能,缓解炎症反应,安全高效,值得推广应用。

Objective To discuss the effects of lienal polypeptide injection on immune function and inflammatory reaction of patients with rectal cancer. Methods Ninety-six patients with rectal cancer were selected at Neijiang Downtown District People＇s Hospital from November 2014 to April 2016 and were randomly divided into an observation group and a control group using a random number table with 48 patients in each group. The observation group patients were treated with lienal polypeptide injection combined with calcium folinate ＋ 5-fluorouracil ＋ irinotecan. The control group patients were treated with chemotherapy regimen of calcium folinate ＋ 5-fluorouracil ＋ irinotecan. The immune function,inflammatory reaction,clinical curative efficacy and adverse reactions were compared between the two groups. Results Before treatment,there was no obvious difference in the levels of CD3^＋,CD4^＋,CD8^＋ and natural killer cell between the two groups（ P〈0. 05）. After treatment,the levels of CD3^＋,CD4^＋,CD8^＋and natural killer cell were markedly higher in the two groups patients than before treatment（ P〈0. 01）. The CD8^＋level in the two groups patients was evidently lower than that of before treatment. The levels of CD3^＋,CD4^＋,CD8^＋andnatural killer cell were observably higher in the observation group than in the control group but the CD8^＋level was visibly lower in the observation group than in the control group（ all P〈0. 01）. Before treatment,there was no significant difference in the soluble interleukin-2 receptor and interleukin-8 levels between the two groups patients（ P〈0. 05）. After treatment,the soluble interleukin-2 receptor and interleukin-8 levels were clearly lower in the two groups than before treatment with the observation group dramatically lower than the control group（ all P〈0. 01）. The treatment efficiency was 79. 2% in the observation group,which was apparently higher than 54. 2% of the control group（ P〈0. 01）. The incidence of bone marrow suppression,liver and renal dysfunction,gastrointestinal reaction and oral mucosal inflammation was lower in the observation group than in the control group（ P〈0. 01）. Conclusion Lienal polypeptide injection can efficaciously improve the immune function,and relieve the inflammatory reaction in patients with rectal cancer. It is safe and efficient and is worth of clinical popularization.