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曲妥珠单抗的耐药机制及治疗 被引量:1

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摘要 乳腺癌是妇女最常见的恶性肿瘤,是一种异质性疾病,根据其细胞表面受体类型的不同,需采用不同的治疗策略,常见的受体有孕激素受体(PR)、雌激素受体(ER)和人表皮生长因子受体-2(HER-2)。其中HER-2是具有酪氨酸激酶活性的穿膜受体,参与调控细胞增殖、存活及分化。
出处 《中国肿瘤临床与康复》 2017年第11期1406-1408,共3页 Chinese Journal of Clinical Oncology and Rehabilitation
基金 国家自然科学基金项目(81672715)
关键词 曲妥珠单抗 耐药性 乳腺肿瘤 Trastuzumab Drug resistance Breast neoplasms
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