西洛他唑联合罂栗碱注射液治疗老年人下肢动脉硬化闭塞症的临床观察

Clinical effect of cilostazol combined with papaverine hydrochloride injection in treatment of elderly lower extremity arteriosclerosis obliterans

目的:评价西洛他唑联合罂栗碱注射液治疗老年人下肢动脉硬化闭塞症的效果。方法:52例老年下肢动脉硬化闭塞症患者分别给予西洛他唑(西洛他唑治疗组,n=26)、西洛他唑联合罂栗碱注射液(西洛他唑联合罂栗碱治疗组,n=26)治疗1周,观察两组治疗前后无痛行走时间、毛细血管充盈时间、足部发红时间、足背静脉充盈时间的变化。结果:西洛他唑及西洛他唑联合罂栗碱注射液治疗后较治疗前无痛行走时间未见明显延长,毛细血管充盈时间、足部发红时间、足背静脉充盈时间明显缩短(P<0.01),西洛他唑联合罂栗碱注射液治疗效果更显著(P<0.05)。结论:西洛他唑与罂栗碱注射液联合使用治疗老年人下肢动脉硬化闭塞症,在缩短毛细血管充盈时间、足部发红时间、足背静脉充盈时间方面,效果优于单用西洛他唑治疗法。

Objective：To evaluate the combined therapeatic effect of cilostazol and papaverine hydrochloride injection in elderly patients with lower extremity arteriosclerosis obliterans. Methods： Fifty--two patients with lower extremity arteriosclerosis obliterans were randomly divided into two groups： cilostazol treatment group （C group, n = 26）, cilostazol and papaverine hydrochloride injection treatment group （CP group, n = 26）, C group was treated with cilostazol, CP group was treated with cilostazol combined with papaverine hydrochloride injection.Painless walking test（PWT） and venous filling time of dorsalis pedis vein （VFTDPV） and capillary filling time of dorsalis pedis（CFTDP） and extremities redness time（ERT） were measured before and after 7 days of therapy.Results： The PWT was not different between the two groups, VFTDPV, CFTDP and ERT were significantly decreased in two groups （P〈 0.01） after treatment, and the CP group decreased more compared with C group （P〈 0.05）. Conclusion： Compared with cilostazol treatment, combined treatment with cilostazol and papavexine hydrochloride injection has a good effect on improvement of VFTDPV and CFTDP and ERT in the treatment of elderly patients with lower extremity arteriosclerosis obliterans.