桃核承气汤预防动脉硬化闭塞症家兔球囊扩张术后再狭窄的实验研究

Prevention of Restenosis by Taohe Chengqi Decoction in Arteriosclerosis Obliterans Rabbits after Balloon Dilatation

目的:观察桃核承气汤对动脉硬化闭塞症家兔模拟球囊扩张术后再狭窄的预防作用。方法:24只家兔造模成功后,全部进行球囊扩张术手术治疗,随机分为中药组和对照组,中药组采用桃核承气汤治疗;对照组采用同剂量的生理盐水,治疗4周后采集血样检测AT-Ⅱ、ET-1、TXB2、NO、6-KPGF1α、CGRP水平,与造模成功后的血液样本比较。结果:桃核承气汤能有效提高CGRP、NO、PGF1α水平(P<0.01),降低ET-1、AT-II、TXB2水平(P<0.01),治疗效果优于空白对照组(P<0.01)。结论:桃核承气汤对动脉硬化闭塞症家兔球囊扩张术后再狭窄有显著预防作用。

Objective ： To observe the preventive effect of Taohe Chengqi decoction for restenosis in arteriosclerosis obliterans rabbits after balloon dilatation. Methods-24 model rabbits were randomly divided into the Chi- nese medicine group and the control group after being performed balloon dilatation. Chinese medicine group was treated with Taohe Chengqi decoction, whereas the control group was fed with normal saline. After 4 weeks, the levels of AT - II, ET - 1, TXB2, NO, 6 - K - PGF1α, and CGRP were tested and compared to those before treatment. Results ： Taohe Chengqi decoction significantly reduced ET, TXB2 and AT - 11 and in- creased NO, CGRP, 6 -K- PGF1α（P 〈0.01 ）, which were better than the control group（P 〈0. 01 ）. Conclusion： Taohe Chengqi decoction has a remarkable preventive effect for restenosis in arteriosclerosis obliterans rabbits after balloon dilatation.