御风胶囊抗脑缺血的药效学研究

Pharmacodynamics Study of Yufeng Capsule in the Treatment of Cerebral Ischemia

目的:研究御风胶囊对实验性脑缺血大鼠的治疗作用。方法:造模成功Wistar大鼠随机分为空白对照组、模型组、阳性药对照组、御风胶囊组4组,观察御风胶囊对模型大鼠脑组织含水量、脑组织病理形态学、血小板聚集率、颈动脉体内血栓、凝血时间等指标的影响。结果:御风胶囊组与模型组比较,能明显降低脑缺血模型大鼠脑组织含水量,改善脑织病理形态学,使血小板聚集率降低,降低颈动脉体内血栓重,延长凝血时间。结论:御风胶囊对实验大鼠的脑缺血具有很好的治疗作用。

Objective ： To explore the therapeutic effect of Yufeng capsule in the treatment of cerebral ischemia in rats. Methods： The successful models were randomly divided into the blank control group, the model group, the positive control group, and Yufeng capsule group. Water content and pathomorphology of the brain tissue, platelet aggregation rate, carotid thrombosis, and blood clotting time were observed to evaluate the effect of Yufeng capsule. Results： The therapy of Yufeng capsule can obviously improve the above indicators when compared to those of the model group. Conclusion： Yufeng capsule has a very good therapeutic effect on cerebral ischemia in rats.