中晚期宫颈癌调强适形放射治疗与常规放疗疗效及不良反应的比较

The comparison of the curative effect and untoward effect between intensity-modulated radiation therapy and conventional radiotherapy for patients with locally advanced cervical cancer

目的比较中晚期宫颈癌盆腔调强适形放射治疗与常规放疗的临床疗效及不良反应。方法将本院2012年8月至2016年12月收治的77例经病理确诊的ⅡB~ⅣA期宫颈癌患者根据时间顺序分为调强适形放射治疗(intensity-modulated radiotherapy,IMRT)组39例及常规放射治疗(conventional radiotherapy,CRT)组38例,分析两组的疗效及不良反应情况。结果 IMRT组与CRT组的近期总有效率(完全缓解+部分缓解)分别为94.9%、92.1%,差异无显著性(P>0.05);骨髓抑制发生率两组间差异无显著性(P>0.05),皮肤反应、胃肠道及泌尿系放疗反应IMRT组明显低于CRT组,差异有显著性(P<0.05)。结论与常规放疗相比,采用调强适形放射治疗治疗技术治疗中晚期宫颈癌,虽未能改善近期总有效率,但能明显降低放疗不良反应的发生率。

Objective The purpose of this study was to compare the treatment outcomes and toxicity between intensity-modulated radiotherapy （IMRT） and conventional radiotherapy （CRT） for patients with locally advanced carcinoma of the cervix in a single institution. Method The retrospective observation to 77 patients with stage II B-IVA cervical carcinoma which were specific diagnosed by pathological examination between August 2012 and December 2016.Thirty-nine patients were treated by intensity-modulated radiotherapy（IMRT）, and the others were treated by conventional radiotherapy （CRT）. We compared short term efficacy and complications between two groups. Result The short term efficacy（CR＋PR） of IMRT group and CRT group were 94.9% and 92.1% respectively, the occurrence rate of myelosuppression between two groups has no statistic difference（P〉0.05）, the occurrence rate of skin reaction,radiation enteritis, urinary system reaction has significant statistic difference（P〈0.05）, Conelusion Compared with CRT in locally advanced cervical cancer, IMRT did not improve the recent total effective rate.But significantly reduced the occurrence rate of toxic response to radiation therapy.