提高移植细胞在心肌梗死区域存活率的研究进展

Advance of improving the survival rate of transplanted cells in myocardial infarction area

心肌梗死等心血管疾病是人类死亡的主要原因之一.心肌梗死区域的心肌细胞数量减少,导致心脏代谢失调,心肌纤维化,以及心力衰竭.目前心肌梗死主要治疗手段有：规范化药物治疗、心脏冠状动脉支架置入、冠状动脉旁路移植术及心脏移植等.上述方法均有局限性,尤其是心肌梗死后治疗心肌纤维化和心室重构所致的心功能不可逆性降低的手段有限.细胞移植疗法能修复坏死心肌,为心肌再生提供可能,已成为治疗心肌梗死的潜力方式之一.本文对控制移植细胞存活因素,提高移植细胞存活的潜在对策作一综述.

Myocardial infarction and other cardiovascular diseases are one of the main causes of human death.Myocardial infarction leads to a reduction in the number of regional myocardial cells,cardiac decompensation,myocardial fibrosis,and heart failure.At present,the main treatment methods of myocardial infarction include drug therapy,coronary stent implantation,coronary artery bypass grafting and heart transplantation.However,these methods have limitations.In particular,irreversible heart failure cause by myocardial fibrosis and ventricular remodeling is difficult to treat.Cell transplantation therapy can repair necrotic myocardium,which may provide a potential for myocardial regeneration.However,the survival rate of transplanted cells is low,which affects the effect of transplantation.The review focuses on the development of cell transplantation therapy in recent years and the factors that improve the survival rate of transplanted cells.