环状RNA在肿瘤中的研究进展

Research Progress on Tumor-related Circular RNA

环状RNA(circular RNA,circRNA)是一类由mRNA 3′及5′末端首尾相连形成的无蛋白编码功能的RNA分子,研究发现其可通过调节肿瘤相关基因转录水平及转录后水平来促进肿瘤的发病,并与肿瘤的转移、预后等显著相关。该文通过总结环状RNA在肿瘤中的研究进展,发现其可通过与miRNA的海绵作用以及调控肿瘤信号通路因子的方式在肿瘤的发生发展中发挥相应作用。环状RNA在肿瘤发病中作用的具体分子机制研究,可为肿瘤的预防、早期诊断及精准治疗提供一种全新的理论支持。

Circular RNA（circRNA） is a class of RNA molecules with interlinked 3′ and 5′ends, which has no protein-coding function. Studies have indicated that circRNA regulates tumor related gene transcription and post-translational processing to initiate tumorigenesis and progression, it is also associated with tumor metastasis and prognosis. In tumorigenesis and progression circRNA acts as “microRNA sponge” to regulate tumor signal pathways. The study of molecular mechanisms of circRNA in tumorigenesis and progression may provide a novel theoretical basis for prevention, diagnosis and precise therapy of tumor.