摘要
使用自制拆分剂对甲苯磺酰胺基-D-苯甘氨酸拆分新型抗癫痫药普瑞巴林的外消旋体,拆分率约为40%,以3-(氨甲酰甲基)-5-甲基己酸为原料制备S-普瑞巴林的总收率为31.95%.
A new chiral resolution agents of（4-methyl phenyl）sulfonyl amino-D-benzeneacetic acid was disclosed to obtain a new antiepileptic drug S-pregabalin.The yield was 40% and the total percent recovery from 3-（carbamoylmethyl）-5-methylhexanoic acid was 31.95%.
出处
《河北师范大学学报（自然科学版）》
CAS
2017年第6期516-520,共5页
Journal of Hebei Normal University：Natural Science
基金
河北省人才工程培养经费项目(A201400346)
关键词
抗癫痫药
普瑞巴林
拆分工艺
对甲苯磺酰胺基-D-苯甘氨酸
antiepileptic drug
pregabalin
resolution process
（4-methyl phenyl）sulfonyl amino-D-benzeneacetic acid
