薜荔叶的化学成分研究

Chemical Constituents from Leaves of Ficus pumila

目的:研究薜荔叶的化学成分。方法:采用硅胶柱层析、ODS、Sephadex LH-20、HPLC等色谱分离方法进行化合物的分离纯化,根据理化性质和波谱数据鉴定各单体化合物的结构。结果:从薜荔叶中分离得到11个化合物,分别鉴定为:蒲公英赛醇(1)、蒲公英萜醇乙酸酯(2)、(23Z)-cycloart-en-3β,25-di-ol(3)、3β-acetoxycycloartan-24-al(4)、(24R)-6β-hydroxy-24-ethyl-cholest-4-en-3-one(5)、β-谷甾醇(6),7-keto-β-sitosterol(7)、反式对羟基肉桂酸乙酯(8)、pubinernoid A(9)、dihydrodehydrodiconiferyl alchol(10)、羟吲哚(11)。结论:其中,化合物4和9~11均为首次从该属植物中分离得到,化合物2、4、5和8~11为首次从该植物中分离得到。

Objective：To study the chemical constituents of Ficus pumila. Methods：The chemical constituents were separated and purified by silica gel, ODS column chromatographies, Sephadex LH-20, and preparative HPLC. Their structures were determined by physicochemical properties and spectral data analysis. Results：Eleven compounds were isolated from Ficus pumila, their structures were identified as taraxerol （ 1 ）, taraxeryl actate （ 2 ）, （23Z） -cycloart-en-3β,25-di-ol （ 3 ）, 3/3-acetoxycycloartan-24-al （ 4 ）, （ 24R ） -6β-hyo- droxy-24-ethyl-cholest-4-en-3-one （5） ,β-sitosterol （ 6 ）, 7-keto-β-sitosterol （ 7 ）, trans-p-hydroxyl ethyl cinnamate （ 8 ）, pubinemoid A （ 9）, dihydrodehydrodiconiferyl alchol （10） and oxindole （ 11 ）. Conclusion ： Compounds 4 and 9 - 11 are reported from Ficus genus for the first time ,compounds 2,4,5 and 8 - 11 are isolated from this plant for the first time.