小叶地不容块根的化学成分研究

Chemical Constituents from the Tuberous Roots of Stephania succifera

目的:研究小叶地不容块根的化学成分。方法:应用多种柱色谱技术进行分离纯化,通过波谱数据和理化性质鉴定化合物的结构。结果:从小叶地不容块根中分离鉴定了11个化合物,分别为:去氢克班宁(1)、左旋四氢巴马汀(2)、克班宁(3)、(-)-sukhodianine-β-N-oxide(4)、promucosine(5)、(-)-sukhodianine(6)、4-hydroxycrebanine(7)、N-methylasimilobine-2-O-β-D-glucopyranoside(8)、巴马汀(9)、(+)-stepharine(10)、(-)-asimilobine(11)。结论:其中,化合物5为首次从千金藤属植物中分离得到,化合物5、7、8和10为首次从该植物中分离得到。

Objective：To study the chemical constituents from the tuberous roots of Stephania succifera.Methods：The compounds were isolated and purified by various chromatographic methods,and their structures were elucidated by spectroscopic methods and physicochemical properties.Results：Eleven alkaloids were isolated and identified as dehydrocrebanine（1）,L-tetrahydropalmatine（2）,crebanine（3）,（-）-sukhodianine-β-N-oxide （4）,promucosine （5）,（-）-sukhodianine （6）,4-hydroxycrebanine （7）,N-methylasimilobine-2-O-β-D-glucopyranoside （8）,palmatine （9）,（＋）-stepharine （10） and （-）-asimilobine （11）.Conclusion：Compound 5 is isolated from Stephania genus for the first time,and compounds 5,7,8 and 10 are isolated from this plant for the first time.