PI3K／AKT信号通路与心肌缺血再灌注损伤被引量：7

PI3K/AKT signaling pathway and myocardial ischemia-reperfusion injury

下载PDF

导出

摘要心肌缺血再灌注损伤（myocardial ischemia-reperfusion injury, MIRI）是各种缺血性心肌病再灌注治疗过程中不可避免的，并且随着冠状动脉介入治疗及溶栓治疗的广泛开展，减轻缺血再灌注损伤对提高再灌注疗效显得尤为重要。目前研究认为MIRI的机制主要与炎症因子释放、氧自由基产生、钙离子超载、线粒体损伤和能量代谢障碍及中性粒细胞浸润有关。

作者孙凤娟赵圣刚江力勤

机构地区蚌埠医学院究生部嘉兴学院附属第二医院心血管内科

出处《中国心血管病研究》 CAS 2017年第11期968-972,共5页 Chinese Journal of Cardiovascular Research

基金浙江省中医药科学研究基金计划（项目编号：2015ZA204）

关键词 PI3K/AKT 信号通路心肌缺血再灌注损伤 PI3K/AKT Signaling pathway Myocardial ischemia-reperfusion injury

分类号 R542.2 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献2

1Mei-qi ZHANG,Yue-liang ZHENG,Huan CHEN,Jian-feng TU,Ye SHEN,Jun-ping GUO,Xiang-hong YANG,Shu-ren YUAN,Liang-zhong CHEN,Jing-jie CHAI,Jian-hong LU,Chang-lin ZHAI.Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway[J].Acta Pharmacologica Sinica,2013,34(11):1386-1396. 被引量：32
2Man-man ZHAO,Jin-yan YANG,Xin-bao WANG,Chao-shu TANG,Jun-bao DU,Hong-fang JIN.The PI3K/Akt pathway mediates the protection of SO2 preconditioning against myocardial ischemia/ reperfusion injury in rats[J].Acta Pharmacologica Sinica,2013,34(4):501-506. 被引量：19

二级参考文献31

1王幼林,陈念航,丁建花.丹参酮ⅡA磺酸钠对大鼠心，脑微粒体Na~＋，K~＋－ATP酶的抑制作用[J].中国药理学与毒理学杂志,1994,8(1):19-23. 被引量：4
2左玉姣,李颖庆,王刚.丹参酮ⅡA磺酸钠对冠心病心绞痛及血液流变学疗效观察[J].现代生物医学进展,2007,7(5):732-734. 被引量：23
3Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124-36.
4Toller WG, Kersten JR, Gross ER, Pagel PS, Warltier DC. Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins. Anesthesiology 2000; 92: 1400-7.
5Shapiro R. Genetic effects of bisulfite (sulfur dioxide). Mutat Res 1977; 39: 149-75.
6Stipanuk MH, Dominy JE Jr, Lee Jl, Coloso RM. Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr 2006; 136: 1652S-1659S.
7Meng Z, Zhang B. Polymerase chain reaction-based deletion screening of bisulfite (sulfur dioxide)-enhanced gpt-mutants in CH0-AS52 cells. Mutat Res 1999; 425: 81-5.
8Mottley C, Trice TB, Mason RP. Direct detection of the sulfur trioxide radical anion during the horseradish peroxidase-hydrogen peroxide oxidation of sulfite (aqueous sulfur dioxide). Mol Pharmacol 1982; 22: 732-7.
9Reed GA, Ryan MJ, Adams KS. Sulfite enhancement of diolepoxide mutagenicity: the role of altered glutathione metabolism. Carcinogenesis 1990; 11:1635-9.
10Zhang RY, Du JB, Sun Y, Chen S, Tsai HJ, Yuan L, et at. Sulfur dioxide derivatives depress L-type calcium channel in rat cardiomyocytes. Clin Exp Pharmacol Physiol 2011; 38: 416-22.