重组人脑利钠肽治疗内蒙古东部地区心力衰竭患者的临床疗效浅析

Clinical efficacy of recombinant human brain natriuretic peptide in the treatment of heart failure in east- ern Inner Mongolia

目的探讨重组人脑利钠肽（新活素）治疗内蒙古东部地区心力衰竭患者的临床疗效。方法选取2015年11月至2016年9月在赤峰学院附属医院心力衰竭病房住院治疗的心力衰竭患者110例，按治疗方案分为2组：观察组（脑利钠肽组）55例和对照组（硝酸甘油组）55例。观察组在常规心力衰竭的治疗方案上应用新活素；对照组在常规治疗治疗方案上应用硝酸甘油治疗。对比两组患者的临床疗效及对改善心功能的影响。结果观察组临床总有效率达91％，优于对照组的67％（P〈0．05）。治疗后NT-proBNP较治疗前明显改善，且观察组治疗后NT—proBNP下降明显[对照组（5900±113．4）pg／ml比观察组（3249±113．4）pg／ml]，两组差异有统计学意义（P00O．05）。结论新活素治疗心力衰竭的临床疗效确切，值得在内蒙古赤峰地区推广应用。

Objective To investigate the clinical efficacy of recombinant human brain natriuretic peptide （rhBNP） in the treatment of heart failure in the eastern part of Inner Mongolia. Methods From November 2015 to September 2016, 110 patients with heart failure were chosen from Affiliated Hospital of Chifeng College. Accord- ing to the treatment plan, the patients were randomly divided into two groups： observation group treated with rhB- NP（n=55） and the control group treated with nitroglycerin （n=55）. The clinical efficacies of the two groups were compared and their influence in improving cardiac function were observed. Results In observation group, the total effective rate was 91%, which was higher than the control group （effective rate, 67% ）（P〈0.05）. In observation group, the NT-proBNP was decreased significantly, there was significant difference between the two groups[the control group （5900±113.4）pg/ml vs observation group （3249±113.4）pg/ml, P〈0.05]. Conclusion The clinical efficacy of rhBNP in the treatment of heart failure is effective, and it is worthy of popularization and application in Chifeng District of Inner Mongolia.