关注炎症性肠病患者的真菌感染问题

Focus on Fungal Infections in Patients With Inflammatory Bowel Disease

尽管肠道内真菌数量仅占肠道微生态的很小一部分,但可能参与或促进炎症性肠病(IBD)的发病。由于IBD患者的免疫功能失衡,药物使用(如免疫抑制剂、生物制剂等)可能使机体抵抗力下降,易导致真菌感染。深部真菌感染死亡率较高。肠道真菌感染易被误认是IBD疾病活动,不易获得早期诊断和治疗。一旦怀疑真菌感染,可综合真菌学和真菌遗传学信息、真菌抗原和血清抗体检测以及影像学等进行诊断,并进行相应的治疗。

Although only a small amount of intestinal fungi is accounted for intestinal microflora, they may participate in or promote pathogenesis of inflammatory bowel disease （IBD）. The immune function of IBD patient might be reduced by some medications （such as immunosuppressive agents, biological agents）, and is therefore more susceptible to fungal infection. The mortality of deep fungal infection is quite high, and intestinal fungal infection might be misinterpreted as the activity of IBD and could not be early diagnosed and treated. Once fungal infection is suspected, diagnosis of fungal infection could be established through the fungal and fungal genetic information, detection of fungal antigen and antibody and imaging examination, thus appropriate treatment could be administered.