丹红注射液联合氯吡格雷治疗急性脑梗死的疗效观察

Observation on Efficacy of Danhong Injection Combined with Clopidogrel in Treatment of Acute Cerebral Infarction

目的:探讨丹红注射液联合氯吡格雷治疗急性脑梗死的临床疗效。方法:选取2015年5月—2017年3月英德市人民医院收治的急性脑梗死患者96例作为研究对象,以随机数字表法分为观察组和对照组,每组48例。对照组患者给予氯吡格雷,观察组患者在对照组基础上加用丹红注射液,两组患者均连续治疗2周。观察两组患者的临床疗效、美国国立卫生研究院卒中量表评分、日常生活活动能力量表评分、血液流变学指标及不良反应发生情况。结果:观察组患者的总有效率为89.58%(43/48),明显高于对照组的72.92%(35/48),差异有统计学意义(P<0.05);治疗后,两组患者美国国立卫生研究院卒中量表评分、日常生活活动能力量表评分均明显优于治疗前,且观察组患者明显优于对照组,差异均有统计学意义(P<0.05);治疗后,两组患者血浆黏度、高切血浆黏度、低切血浆黏度、血浆还原比黏度和纤维蛋白原水平明显低于治疗前,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05);观察组、对照组患者的不良反应发生率分别为10.42%(5/48)、14.58%(7/48),两组的差异无统计学意义(P>0.05)。结论:丹红注射液联合氯吡格雷治疗急性脑梗死的疗效确切,能改善患者神经功能,提高患者日常活动能力。

OBJECTIVE：To probe into the clinical efficacy of Danhong injection combined with clopidogrel in treatment of acute cerebral infarction .METHODS：96 patients with acute cerebral infarction admitted into the People ＇ s Hospital of Yingde from May 2015 to Mar.2017 were selected and divided into observation group and control group via random number table , with 48 cases in each .The control group was treated with clopidogrel , while the observation group was given Danhong injection combined with clopidogrel , both groups received a 2-week treatment .Clinical efficacy , scores of National Institutes of Health Stroke Scale （ NIHSS ） and Activities of Daily Living （ ADL ） , indices of hemorheology and incidences of adverse drug reactions of two groups were observed .RESULTS：The total effective rate of observation group （89.58%, 43/48 ） was significantly better than that of the control group （ 72.92%, 35/48 ） , with statistically significantly difference （ P〈0.05）; after treatment , the NIHSS score and ADL score of both groups were significantly better than those of before treatment , and those of observation group was significantly better than the control group, with statistically significantly differences （ P 〈0.05 ）; after treatment , plasma viscosity , high shear plasma viscosity , low shear plasma viscosity , blood reduction viscosity and fibrinogen of both groups were significantly lower than those of before treatment , and those of observation group were significantly lower than the control group , with statistically significantly differences （ P〈0.05 ）;incidences of adverse drug reactions of observation group and control group were respectively 10.42% （ 5/48 ） and 14.58% （ 7/48 ） , the difference had no statistical significance （ P 〉0.05 ） . CONCLUSIONS：The efficacy of Danhong injection combined with clopidogrel in treatment of acute cerebral infarction is remarkable , which can improve patients ＇ neurologic and capacities of daily activities .