血液灌流联合血必净注射液治疗急性重度有机磷农药中毒的疗效及对炎性因子水平的影响

Efficacy of Hemoperfusion Combined with Xuebijing Injection in Treatment of Acute Severe Organophosphorus Pesticide Poisoning and Its Effect on Inflammatory Factors

目的:探讨血液灌流联合血必净注射液治疗急性重度有机磷农药中毒的疗效及对炎性因子水平的影响。方法:选取2009年12月—2016年12月内蒙古赤峰学院附属医院收治的急性重度有机磷农药中毒患者90例作为研究对象,以随机数字表法分为观察组和对照组,每组45例。观察组患者给予血液灌流联合血必净注射液,对照组患者仅给予血必净注射液。观察两组患者意识改善时间、血浆胆碱酯酶水平、血清炎性因子水平及并发症发生情况。结果:观察组患者意识改善时间为(1.40±0.42)d,明显短于对照组的(2.81±0.67)d,差异有统计学意义(P<0.05);治疗后,观察组患者血浆胆碱酯酶水平为(1 241.22±89.42)U/L,明显高于对照组的(843.21±67.78)U/L,差异有统计学意义(P<0.05);治疗后,两组患者白细胞介素1β、白细胞介素6和白细胞介素8水平明显低于治疗前,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05);两组患者并发症发生率的差异无统计学意义(P>0.05)。结论:血液灌流联合血必净注射液治疗急性重度有机磷药中毒的疗效显著,可降低血清炎性因子水平。

OBJECTIVE：To probe into the efficacy of hemoperfusion combined with Xuebijing injection in treatment of acute severe organophosphorus pesticide poisoning （ ASOPP ） and its effect on inflammatory factors . METHODS：90 patients with ASOPP admitted into the Affiliated Hospital of Inner Mongolia Chifeng University from Dec.2009 to Dec.2016 were selected and divided into observation group and control group via random number table , with 45 cases in each .The observation group was given hemoperfusion combined with Xuebijing injection , while the control group was treated with Xuebijing injection alone .Improvement times of consciousness , levels of plasma cholinesterase and serum inflammatory factors , and incidences of complications of two groups were observed . RESULTS：The improvement time of consciousness of observation group [（1.40 ±0.42） d] was significantly shorter than that of the control group [ （ 2.81 ±0.67 ） d ] , with statistically significantly difference （ P 〈0.05 ）; after treatment, level of plasma cholinesterase of observation group [（1241.22 ±89.42） U/L] was significantly higher than that of the control group [（843.21 ±67.78） U/L], with statistically significantly difference （P〈0.05）; after treatment, levels of interleukin-1β, interleukin-6 and interleukin-8 were significantly lower than those of before treatment , and those of observation group were significantly lower than the control group , with statistically significantly differences （ P 〈0.05 ）：there was no statistical significance in the difference of complications between two groups （P〉0.05）.CONCLUSIONS：The efficacy of hemoperfusion combined with Xuebijing injection in treatment of ASOPP is remarkable , which can reduce the level of serum inflammatory factors .