临床药师对抗菌药物致急性药物性肝损伤的药学监护

Pharmaceutical Care for Patients with Antibiotics Causing Acute Drug-Induced Liver Injury by Clinical Pharmacists

目的:探讨临床药师对抗菌药物致急性药物性肝损伤(drug induced live injury,DILI)的药学监护切入点。方法:临床药师参与1例抗菌药物导致急性DILI患者的诊治过程,并对患者进行药学监护及用药指导。结果:该患者考虑为抗菌药物致急性DILI的可能性大,临床药师协助临床医师制订和完善了治疗方案,进行保肝护肝等对症处理后,患者肝功能明显好转。结论:急性DILI的病因及发病机制复杂,临床应加强对抗菌药物致DILI的重视;临床药师应利用所掌握的药学知识,充分发挥自己的业务专长,积极参与临床治疗,促进合理用药。

OBJECTIVE：To probe into the point of pharmaceutical care for patients with antibiotics causing acute drug-induced liver injury （ DILI） by clinical pharmacists .METHODS：Clinical pharmacists participated in treatment of 1 case of antibiotics causing acute DILI , processed pharmaceutical care and medication guidance .RESULTS：This patient with acute DILI was likely to be caused by antibiotics , clinical pharmacists gave assistance to clinicians in the formulating and perfection of therapeutic regimen , patient＇s hepatic function went better after the heteropathy of liver protection.CONCLUSIONS：The cause and pathogenesis of acute DILI are complicated , attention on antibiotics inducing DILI needs to be reinforced;clinical pharmacists should make full use of pharmaceutical knowledge and give full play of specialized skills , take active participation in clinical treatment , so as to promote rational medication .