脑梗死后焦虑的生物学指标及相关因素分析

Analysis of biological index and related factors of anxiety post cerebral infarction

目的探讨血浆同型半胱氨酸水平与脑梗死后焦虑发生的相关性。方法对经头颅CT和(或)MRI确诊的200例脑梗死患者进行进行一般资料、美国国立医院脑梗死量表(NIHSS)、汉密尔顿焦虑量表(HAMA)14项版本调查,分析结果,分为脑梗死后焦虑组和对照组,同时所有患者检测同型半胱氨酸,分析同型半胱氨酸与脑梗死后焦虑发生的相关性。结果脑梗死后焦虑组同型半胱氨酸水平(24.86±7.21)μmol/L明显高于对照组(12.62±3.40)μmol/L,差异具有显著性(P﹤0.05)。将脑梗死后焦虑患者进行轻、中、重分组比较,差异具有显著性(P﹤0.05)。结论脑梗死后焦虑的发生可能与同型半胱氨酸水平相关,其严重程度可能与同型半胱氨酸水平相关。

Objective To investigate the relationship between plasma homocysteine level and anxiety in patients with cerebral infarction. Methods The general data of 200 patients with cerebral infarction diagnosed by CT and/or MRI were investigated by using the National Hospital cerebral infarction scale（NIHSS） and Hamilton Anxiety Scale（HAMA） 14, and the result is analyzed. The patients were divided into anxiety group and control group after cerebral infarction, and at the same time, homocysteine was detected in all patients, and the correlation between homocysteine and anxiety post cerebral infarction was analyzed. Results In the post cerebral infarction, the level of homocysteine（24.86±7.21） mol/L in anxiety group was significantly higher than that in control group（12.62±3.40）μmol/L, and the difference was significant（P﹤0.05）. There were significant differences between the groups with mild, moderate and severe anxiety post cerebral infarction（P﹤0.05）. Conclusion The occurrence of anxiety after cerebral infarction may be related to the level of homocysteine, and the severity may be related to the level of homocysteine.