大剂量乌司他丁治疗脓毒性休克的临床疗效

Investigation on the clinical efficacy of large dose of ulinastatin in the treatment of septic shock

目的:分析大剂量乌司他丁运用在脓毒性休克治疗中的效果。方法:收治脓毒性休克患者40例,随机平分为对照组和观察组。均给予常规集束化抗休克治疗和病因治疗,观察组在此基础上加入大剂量乌司他丁治疗,比较两组治疗效果。结果:两组治疗后的血清PCT、TNF-α、IL-6水平均有所改善,但组间比较,观察组均有明显的优势(P<0.05);两组多器官功能衰竭和ICU住院时间比较,观察组同样有明显的优势(P<0.05)。结论:在脓毒性休克患者的治疗中使用大剂量乌司他丁进行治疗,可进一步提升治疗效果。

Objective:To investigate the clinical efficacy of large dose of ulinastatin in the treatment of septic shock.Methods:40 patients with septic shock were selected.They were randomly divided into the two groups on average.They were all given routine cluster anti shock therapy and etiological treatment.On this basis,the observation group was treated with large dose of ulinastatin.The therapeutic effects of the two groups were compared.Results:After treatment,the levels of serum PCT,TNF-α and IL-6 in the two groups were improved,but the observation group had obvious advantages(P<0.05).The two groups of patients in multiple organ failure and ICU hospitalization time comparison,and the observation group also had a clear advantage(P<0.05).Conclusion:Large dose of ulinastatin can improve the therapeutic effect in the treatment of septic shock.