正性音乐刺激联合舍曲林治疗对首发抑郁症大学生焦虑抑郁情绪及生活质量的影响

Effects of Positive Music Stimulation Combined with Sertraline on Anxiety,Depression and Quality of Life in College Students with First-Episode Depression

目的探讨正性音乐刺激联合舍曲林治疗对首发抑郁症大学生焦虑抑郁情绪及生活质量的影响。方法运用随机数字表法将2016年10—12月上海市浦东新区精神卫生中心及嘉定区精神卫生中心治疗的60例首发抑郁症大学生分为对照组(给予舍曲林治疗)和观察组(舍曲林联合正性音乐刺激治疗),每组30例。分别于入组时、干预4周、干预8周和干预12周对首发抑郁症大学生进行焦虑自评量表、抑郁自评量表和生活质量综合评定问卷等问卷调查,比较2组大学生焦虑抑郁情绪、生活质量及药物不良反应。结果治疗后,观察组相应时点焦虑自评量表得分及抑郁自评量表得分显著低于对照组,而相应时点GQOLI-74总分显著高于对照组(均P<0.05)。结论正性音乐刺激联合舍曲林治疗能够明显改善首发抑郁症大学生焦虑抑郁情绪,提高大学生生活质量,疗效优于单用舍曲林治疗。

Objective To explore the effects of positive music stimulation combined with ser-traline on anxiety,depression and quality of life in college students with first-episode depression. Methods Sixty college students with first-episode depression were randomly treated with sertra-line alone（control group）or in combination with positive music stimulation（observation group）in Mental Health Center of Pudong New Area and Mental Health Center of Jiading District from October 2016 to December 2016.In addition,students were surveyed by Self-Rating Anxiety Scale,Self-Rating Depression Scale and Generic Quality of Life Inventory-74 before and treatment for 4,8 and 12 weeks.The anxiety,depression,quality of life and adverse drug reactions were compared between the two groups.Results Compared with control group,the scores of Self-Rat-ing Anxiety Scale and Self-Rating Depression Scale decreased and the scores of Generic Quality of Life Inventory-74 increased in observation group after treatment（P 〈 0.05）.Conclusion The combination of positive music stimulation and sertraline is superior to sertraline alone for impro-ving the anxiety and depression and enhancing the quality of life in college students with first-epi-sode depression.Therefore,the combined treatment is worthy of application and promotion.