摘要
血栓闭塞性脉管炎(thromboangiitis obliterans,TAO)又称Buerger’s病,是一种血管炎性、节段性、反复发作的慢性阻塞性疾病,主要累及四肢远端中小血管尤其是下肢血管。TAO发病机制主要与吸烟、免疫、感染、炎症、同型半胱氨酸以及性激素基因有关,近年来有关免疫和微生物感染因素在TAO发生中的作用相关研究较多。文章就免疫和感染在TAO发生中的作用研究进展进行综述,以期提高对TAO发病机制的认识。
Thromboangiitis obliterans（TAO）,also known as Buerger＇s disease,is a segmental and recurrent episode of chronic obstructive vasculitis,which mainly involves the distal limbs of small blood vessels and nerves,especially the lower extremity arteries.It has been suggested that TAO is related to smoking,immunity,infection,inflammation,homocysteine and sex hormone-re-lated genes.This paper reviews the recent advances in the role of immunology and molecular biol-ogy in TAO to improve our understanding of its pathogenesis.
出处
《南昌大学学报（医学版）》
CAS
2017年第5期85-89,共5页
Journal of Nanchang University：Medical Sciences
基金
国家自然科学基金(81660751
81660151
81260504)
江西省重点研发计划项目(20161BBG70067)
江西省自然科学基金项目(2017ZRMS2187
关键词
血栓闭塞性脉管炎
发病机制
免疫
感染
thromboangiitis obliterans
pathogenesis
immune
infection
