MicroRNA调控神经突触囊泡循环的研究进展

Progress of Research on MicroRNA in Regulating Synaptic Vesicle Recycling

microRNAs(miRNAs)是一类大约含有22个核苷酸的单链非编码小分子RNA,通过对mRNA转录及稳定性的负向调控对基因表达具有重要作用。miRNAs在脑组织中大量表达,对神经元的生长发育以及神经功能的调节均发挥重要作用。神经信号传递始于神经递质从突触囊泡的释放。突触囊泡需要经历释放-回收的动态过程以维持突触前终末的结构和功能的完整性,此过程称之为囊泡循环。随着研究的深入,发现miRNA在神经突触中起着重要的作用。本文将对miRNA对神经突触囊泡循环的调节作用做一综述。

Micro RNAs(mi RNAs) are a class of small22 nucleotides noncoding RNAs that regulate the expression of genes based on the transcription of m RNA and the negative control of stability. mi RNAs are abundant in the brain, where they play key roles in neuron growth and development and in regulation of neural function. Neurotransmission begins with the release of neurotransmitters from synaptic vesicles. Synaptic vesicles endure the dynamic "releaserecycle" process to maintain the function and structure of presynaptic terminal. Advancing research has found that mi RNA plays an significant role in neural synapsing. This review focuses on mi RNAs in regulating synaptic vesicle recycling.