二甲双胍联合综合性强化管理对社区糖尿病患者血糖控制及生活质量的改善分析

Improvement Effect of Metformin Combined with Comprehensive Strengthening Management on Blood Glucose Control and Quality of Living of Patients with Diabetes in Community

目的探讨二甲双胍联合综合性强化管理对社区糖尿病患者血糖控制及生活质量的改善。方法选取2014年2月—2017年2月上海市徐家汇街道社区卫生服务中心收治的100例2型糖尿病患者,采用数字随机法均分为观察组与对照组,每组各50例。对照组患者采用常规管理加二甲双胍治疗,观察组患者采用二甲双胍联合综合性强化管理。比较治疗前后空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA_(1c))、体质指数(BMI)改善效果,并采用SF-36量表评价两组患者治疗前后生活质量的改善情况。结果治疗前两组FPG、2 hPG、HbA_(1c)、BMI比较,差异无统计学意义(P>0.05);治疗后观察组FPG、2 hPG、HbA_(1c)较对照组降低,差异有统计学意义(P<0.05)。治疗前两组SF-36量表社会功能、情感职能、生理职能、生理功能、躯体疼痛、总体健康、精神健康、活力评分比较,差异无统计学意义(P>0.05);治疗后观察组SF-36量表社会功能、情感职能、生理职能、生理功能、躯体疼痛、总体健康、精神健康、活力评分均高于对照组,差异有统计学意义(P<0.05)。结论二甲双胍联合综合性强化管理对社区糖尿病患者血糖控制效果较优,相较于常规管理能够显著提升患者生活质量。

Objective To study improvement effect of metformin combined with comprehensive strengthening management on blood glucose control and quality of living of patients with diabetes in community. Methods 100 cases of patients with type 2 diabetes admitted in Xujiahui Street Community Health Service Center in Shanghai from February 2014 to February 2017 were selected,were divided into observation group and control group using a random number table method. Patients in control group were treated with conventional management plus metformin,and the observation group was treated with metformin combined with intensive management. The fasting blood glucose( FPG),2 h postprandial blood glucose( 2 hPG),glycosylated hemoglobin( HbA_(1c)),body mass index( BMI) were compared before and after treatment,SF-36 scale was used to evaluate the improvement of life quality before and after treatment in two groups. Results Before treatment,the FPG,2 hPG,HbA_(1c)and BMI between the two groups were not statistically significant( P > 0. 05); after treatment,FPG,2 hPG,HbA_(1c)in observation group were lower than those in control group,the difference was statistically significant( P < 0. 05). Before treatment,the the scores of social function,role emotional,role physical,physiological function,body pain,general health,mental health and viability between the two groups were not statistically significant( P > 0. 05); after treatment,the scores of social function,role emotional,role physical,physiological function,body pain,general health,mental health and viability in observation group were higher than those in control group, the difference was statistically significant( P < 0. 05). Conclusion Metformin combined with comprehensive strengthening management performs well in control blood glucose of patients with diabetes in community and can improve quality of living for patients distinctly compared with conventional management.