帕罗西汀治疗慢性阻塞性肺疾病患者焦虑和抑郁的疗效分析

Efficacy of Paroxetine on Anxiety and Depression among Patients with Chronic Obstructive Pulmonary Disease

目的了解帕罗西汀对慢性阻塞性肺疾病(COPD)患者焦虑、抑郁的疗效。方法选取2015年10月—2016年10月于浙江省瑞安市人民医院呼吸内科就诊的COPD患者100例为研究对象。采用随机数字表法将患者随机分为常规组和研究组,各50例。常规组给予噻托溴铵,研究组联合帕罗西汀治疗。比较两组患者治疗前后肺功能、运动耐量及汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分。结果常规组与研究组治疗后第1秒用力呼气量(FEV1)、第1秒用力呼气量/呼气容积(FEV1/FVC)、深吸气量(IC)、6 min步行距离(6MWD)比较,差异无统计学意义(P>0.05);研究组HAMA、HAMD评分低于常规组,差异有统计学意义(P<0.05)。结论针对COPD存在焦虑、抑郁患者给予帕罗西汀联合噻托溴铵治疗可有效改善抑郁、焦虑情况,并对肺功能治疗无影响。

Objective To study the efficacy of paroxetine on anxiety and depression among patients with chronic obstructive pulmonary disease. Methods 100 cases of patients with chronic obstructive pulmonary disease admitted in Ruian People's Hospital of Zhejiang from October 2015 to October 2016 were selected and divided into two groups,50 cases in each group. Routine group was provided with conventional treatment with tiotropium bromide,while research group was provide with combination treatment with paroxetine. Patients of two groups were compared for lung function,exercise tolerance and score of HAMA and HAMD before and after treatment. Results After treatment,there was no significant difference in FEV1,FEV1/FVC,IC and 6MWD between routine group and research group( P > 0. 05). The HAMA and HAMD score of patients in research group was lower than that in routine group( P < 0. 05). Conclusion Applying paroxetine combined with tiotropium bromide to anxiety and depression of patients with chronic obstructive pulmonary disease can effectively relieve anxiety and depression,moreover,it has no side effect on treatment of lung function.